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HomePrenatal Screening OptionsLess than 14 Weeks' PregnantNon-Invasive Prenatal Testing (NIPT)
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Non-Invasive Prenatal Testing (NIPT)

Non-invasive Prenatal Testing (NIPT) is the most accurate prenatal genetic screening test and may be OHIP-funded or private-pay depending on your situation. There is no risk to the pregnancy because it is done through blood work. NIPT can tell you the chance for having a baby with trisomy 21 (Down syndrome), trisomy 18 (Edwards syndrome) and other chromosome differences. You can have NIPT from the time you are 9 or 10 weeks pregnant until the end of the pregnancy. 

How to get NIPT

Talk with your health-care provider if you would like to get NIPT. In Ontario, this test can be ordered by:

  • doctors (such as family doctors, obstetricians)
  • nurse practitioners

In Ontario, NIPT cannot currently be ordered by midwives.

Your health-care provider may tell you about the option of going to a genetics centre for more discussion if there are concerns about your pregnancy.

Who should not have NIPT?

You should not have NIPT if you:

  • had a "vanishing" twin / co-twin demise. This is a pregnancy that started as twins, but one of the twins was lost. 
  • are expecting more than two babies (triplets, quadruplets etc).
female provider
For Health-Care Providers

View fact sheet on NIPT to share with pregnant individuals in your care

NIPT Requisitions and How To Order

Funding for NIPT

The cost of NIPT is funded through Ontario Health Insurance Plan (OHIP) in certain situations. If you cannot have OHIP-funded NIPT, you can choose to pay for this testing yourself. Review each option below to see which one applies to your situation.

OHIP-Funded NIPT

If you are expecting one baby, and meet one of the listed funding criteria, you can have your NIPT covered by Ontario Health Insurance Plan (OHIP).  The blood work for OHIP-funded NIPT is done at either a LifeLabs or Dynacare location, depending on which test you are doing.

If you are expecting twins, you can have OHIP-funded NIPT. OHIP-funded NIPT for twins is usually possible through either LifeLabs or Dynacare. There are two situations when OHIP-funded NIPT should only be done through Dynacare (and not LifeLabs):

  • A twin pregnancy where a donor egg was used
  • A twin pregnancy where a gestational carrier (surrogate) is involved
Private-Pay NIPT

You can choose to pay for private-pay NIPT if you do not meet any of the funding criteria. This means that you would pay for this testing yourself, or you may get it covered through your private health insurance.

If you have not had any screening in your pregnancy, you can consider starting with an OHIP-funded prenatal screening test (eFTS or STS) before deciding to pay out-of-pocket for NIPT. A "screen positive" result from one of these other tests would make it possible for you to have OHIP-funded NIPT. 

Take note that if you are paying for NIPT out-of-pocket, and later in the pregnancy you meet one of the funding criteria, you will not be able to get a refund.

In Ontario, private-pay NIPT is available through the Ontario-based laboratories (LifeLabs or Dynacare), as well as through other laboratories based outside of Canada (blood samples and personal health information is sent out of the country, where the testing is performed).

Prenatal Screening Ontario is unable to endorse any specific private-pay test or laboratory. If you are interested in pursuing private-pay NIPT, please talk to your health-care provider about which test might be best for you.

Here are some questions you or your provider can ask if you are thinking to have private-pay NIPT:

  • Does the laboratory have information available on how well the test performs for each of the screened chromosome differences? Has this information been published in a trusted scientific journal where it was reviewed by other experts?
  • What is the process for ordering NIPT at the laboratory? Can the blood draw be done in your area?
  • Can the testing be limited to trisomy 21, trisomy 18, trisomy 13 and sex chromosome differences? Canadian and international guidelines do not currently support the use of NIPT to screen for other conditions because the accuracy is less well known.
  • What is the cost of NIPT?
  • Is genetic counselling available by the NIPT testing company before and/or after you have NIPT to help you understand the test and results?
  • If the testing is performed outside of Canada, how does the out-of-country laboratory manage and protect your personal health information?

When to get NIPT

You can choose NIPT as the only prenatal genetic screening test in your pregnancy.

If you decide to have NIPT from the start, you do not need another screening test (such as eFTS). You should still be offered a 11-14 week (nuchal translucency) ultrasound on its own to get more information about the health of the baby.

Another option is to start with another OHIP-funded screening test, such as eFTS. Later in the pregnancy, you can think about having NIPT.  

What does NIPT look for?

NIPT detects most pregnancies with trisomy 21, trisomy 18  and trisomy 13. As other screening tests, NIPT cannot detect all pregnancies with these chromosome differences. 

Talk to your health-care provider about screening your pregnancy for sex chromosome differences including Turner syndrome.  This extra test is optional. Keep in mind the accuracy of NIPT for sex chromosome differences is thought to be lower. 

Screening for other conditions

You may be told you can have screening for a group of conditions called microdeletion syndromes as an extra private-pay option. Each microdeletion syndrome is rare on its own and the accuracy of NIPT for these conditions is difficult to study.  So far, we know that NIPT might not be as accurate for these extra conditions.  

Microdeletion syndromes can vary a lot in severity from person to person. It may be difficult to know how these conditions might affect your pregnancy or your baby after birth. 

Current guidelines do not support the use of NIPT to screen for microdeletion syndromes at this time. This may change as more studies are done.

How does NIPT work?

During a pregnancy, your baby's placenta releases small pieces of genetic material (known as DNA) into your blood stream. NIPT looks at this placental DNA and can tell you the chance for the baby to have one of the chromosome differences that are tested.

 

Cell free fetal DNA

 

Illustration adapted from Genetic Counseling Aids, 7th Edition, Copyright 2020, permission for use granted by Greenwood Genetic Center

How long does it take to get results?

It takes about 7 to 10 business days for your health-care provider to get the NIPT results. If NIPT was done through LifeLabs, you may be able view your results online within 5 calendar days of the report being released to your health-care provider.

What will the NIPT results mean?

When you get your NIPT report, it will most likely  say that you have a “low risk” result. This means there is a very low chance that the baby has one of the screened conditions.

Some people will get a “high risk” result. This means there is a high chance that the baby has one of the screened conditions. More testing would be offered to you, including diagnostic testing.

Sometimes, the NIPT does not work. Most of the time, the NIPT "fails" because of reasons outside of your control. It is recommended to have an ultrasound before NIPT blood draw to lower the chance for a "no call" result. An ultrasound tells you if you are having the blood drawn for NIPT at the right time, or if you are expecting more than one baby.

Benefits 

There are three main benefits of NIPT:

Higher accuracy
NIPT is a more accurate screening test compared to other screening tests (eFTS or STS)
Earlier timing
NIPT can be done earlier than other available screening tests.
Safe
As other screening tests, NIPT poses no risk to the pregnancy.

Limitations

NIPT has some of the following limitations:

Not diagnostic
NIPT is a very good screening test but it still cannot give a definite “yes” or “no” answer. Only diagnostic testing (such as chorionic villus sampling or amniocentesis) can do that.
Does not screen for "everything"
A "low risk" result does not guarantee the birth of a healthy baby.
Can fail to give you a result

Occasionally, the NIPT can “fail” to give a result. You might not get a result for any of the chromosome differences that were tested. Or, only the testing for sex chromosome differences might fail.

Other prenatal genetic screening tests (eFTS and STS), will only very rarely fail to give you a result.

Can give you an unexpected result or a result that is not typical
Even more rarely, you can get an unexpected result. For example, NIPT may pick up a difference in your own genetic material. You should talk about this type of result with a genetic counsellor.

 

NIPT after Preimplantation Genetic Testing for Aneuploidy (PGT-A)

Some pregnancies happen through in vitro fertilization (IVF) and the embryos may get Preimplantation Genetic Testing for Aneuploidy (PGT-A) during that process.  PGT-A involves screening embryos for chromosome differences, including trisomy 21 and trisomy 18. It is a very good screen, but not diagnostic.  If your pregnancy was screened using PGT-A, you can see a genetic counsellor to discuss the benefits and limitations of having NIPT in your situation.

 

 

  • Prenatal Screening Options
    • Is Prenatal Screening Right For Me?
    • Less than 14 Weeks' Pregnant
      Toggle Section Less than 14 Weeks' Pregnant Menu
      • Enhanced First Trimester Screening (eFTS)
      • Non-Invasive Prenatal Testing (NIPT)
        Toggle Section Non-Invasive Prenatal Testing (NIPT) Menu
        • NIPT Funding Criteria
      • 11-14 Week (Nuchal Translucency) Ultrasound
    • 14-21 Weeks' Pregnant
      Toggle Section 14-21 Weeks' Pregnant Menu
      • Second Trimester Screening (STS)
      • Non-Invasive Prenatal Testing (NIPT)
        Toggle Section Non-Invasive Prenatal Testing (NIPT) Menu
        • NIPT Funding Criteria
      • 18-22 Week Ultrasound
    • More than 21 Weeks' Pregnant
      Toggle Section More than 21 Weeks' Pregnant Menu
      • Non-Invasive Prenatal Testing (NIPT)
        Toggle Section Non-Invasive Prenatal Testing (NIPT) Menu
        • NIPT Funding Criteria
      • 18-22 Week Ultrasound
    • Twins and More Than Two Babies
    • Vanishing Twins

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