Multiple marker screening (MMS) - most commonly enhanced first trimester screening (eFTS) and maternal serum quadruple screening (MSS-Quad) - is performed in Ontario by 3 provincial MMS laboratories; Trillium Health Partners – Credit Valley Hospital, Mount Sinai Hospital and North York General Hospital.

MMS Requisitions

These requisitions can be used to order enhanced first trimester (eFTS), maternal serum quadruple screening (MSS) in the second trimester, and maternal serum alpha-fetoprotein (MS-AFP) screening for open neural tube defects (only under certain criteria).

• Trillium Health Partners – Credit Valley Hospital requisition
• Mount Sinai Hospital requisition
• North York General Hospital requisition

Points to Consider

When completing the MMS requisition for your patient/client, it is important to consider the following:

1. The clinical information section is to be completed by the ordering provider prior to the bloodwork
2. The ultrasound information section is to be completed by:
   • When ordering eFTS – the sonographer/physician who is measuring the nuchal translucency should complete this section, along with their provider identifier to facilitate NTQA
   • When ordering second trimester MSS - the ordering provider should provide the ultrasound dating information.
3. Missing information decreases the quality of the screen and can potentially delay the results
4. Prenatal screening results will be reported to the ordering provider within 7-10 business days